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Cov tshuaj zoo li cas yog benoxate ntsiav tshuaj

Benorilate tseem paub zoo li paracetamol, antipyretic, thiab benzol. Lub npe tshuaj: 4- (acetamido) phenyl 2- (acetoxy) benzoic acid ester.

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Cov yam ntxwv ntawm benoxate ntsiav tshuaj

Benoate ntsiav tshuaj yog lipophilic compound tsim los ntawm cov tshuaj aspirin thiab paracetamol hydroxyl pawg, uas hloov cov pawg tseem ceeb uas ua rau muaj kuab lom thiab cuam tshuam rau hauv cov qauv-hydroxyl thiab carboxyl pawg, thiab concentrates tshuaj aspirin kom txo tau qhov mob. , Anti-inflammatory nyhuv thiab muaj zog antipyretic nyhuv ntawm paracetamol. Nws hla dhau qhov kev ua tsis tiav ntawm cov tshuaj aspirin thiab aminopyrine rau maj mam txo qhov npaws. Nws muaj cov roj ua tau zoo solubility thiab maj mam hydrolyzed nyob rau hauv cov ntshav kom sib txawv kiag li cov tshuaj aspirin thiab paracetamol monomers. Metabolites, yog li cov nyhuv yog mob tsawg, cov nyhuv curative zoo dua, thiab kev hloov kho kom muaj zog.

1. Tawm nrawm nrawm, zoo xaus nqi thiab siab bioavailability.

2. Qhov uas muaj cov nyom tshwm sim tsawg. Txij li cov khoom no tsis yauv kuaj dej hauv lub plab zom zaws, nws kov yeej txoj kev khaus ntawm kev tawm tsam kev mob nkeeg kom ua rau txoj hnyuv plab, thiab nws tsis quav tshuaj thiab ua rau siv ntev.

3. Nws tsis muaj dab tsi cuam tshuam rau lub hauv nruab nrab lub paj hlwb ntawm lub cev qhov kub thiab txias. Nws zoo dua thiab muaj kev nyab xeeb dua thaum ua ntawv thov rau cov menyuam mos thiab cov menyuam yaus qhov kev tswj ntsuas kub tseem tsis tau paub tab.

4. Tsis muaj tus ntxhiab tsw txawv, tuaj yeem nqa lossis ntxo; ncua ntev noj ntau, tsis muaj kev cuam tshuam txog cov ntshav theem, hematopoietic kev ua haujlwm, kev ua haujlwm siab, lub raum kev ua haujlwm, kev tiv thaiv kab mob. Yog li no, Nochisha yog ib yam tshuaj zoo rau tsev neeg.

Pharmacological cov teebmeem ntawm benoxate ntsiav tshuaj

Tom qab qhov ncauj nqus ntawm Benoate ntsiav tshuaj, nws siv tawm antipyretic nyhuv los ntawm inhibiting cyclooxygenase hauv nruab nrab lub paj hlwb thiab txo cov synthesis ntawm prostaglandin (PG); nws muaj cov nyhuv analgesic los ntawm inhibiting PG synthase hauv cov ntaub so ntswg peripheral; Los ntawm kev txiav txim siab ntawm PG synthesis thaum lub sij hawm teb, cov nyhuv curative coj ua. uas yog:

1. Antipyretic effect: zoo inhibit lub siab pathological ntawm lub cev kub ntawm qhov chaw nruab nrab, txo cov cua sov hauv lub cev; ua kom cov tawv nqaij cov hlab ntshav txhaws, tawm hws ntau, thiab ua kom kub sai ua kom sov (tsis muaj dab tsi cuam tshuam rau lub cev qhov kub).

2. nyhuv analgesic: inhibit qhov kev tsim cov tshuaj tiv thaiv-tiv thaiv, cuam tshuam kev txiav tawm ntawm antigen lub cev; ncaj qha ua rau ntawm qhov chaw txais khoom, tiv thaiv kev tsim cov tshuaj kho mob (PG), thiab muaj cov txiaj ntsig ntawm kev tso tawm cov tshuaj ua kom mob mob thaum tawm tsam cov nqaij mos.

3. Cov nyhuv tshuaj tiv thaiv: tiv thaiv kev tsim cov tshuaj tawm tsam xws li prostaglandin, histamine, plhaw plab, thiab lwm yam, thiab tiv taus lawv cov kev txhawb; ruaj khov lysosomal membrane; txo vascular permeability nyob rau hauv cov ntaub so ntswg ua paug, tshem tawm dej; muaj fibrinolytic Txhim kho microcirculation.

Qhov ntsuas ntawm Benoate ntsiav tshuaj

1. Nws yog siv rau kev kho mob khaub thuas, kub taub hau, thiab lwm yam kab mob, thiab muaj cov nyhuv antipyretic zoo.

2. Ntau cov teebmeem analgesic. Cov tshuaj sab hauv, mob paj hlwb, mob leeg thiab mob caj dab, ENT, thiab lwm yam yog siv rau hauv kev kho mob taub hau, mob hniav, mob neuralgia, mob caj pas thiab mob, mob leeg, mob plab, mob tom qab, mob tom qab, thiab lwm yam, zoo nyob rau hauv 20 feeb, Cov hauj lwm zoo yog tshaj 98%; tshwj xeeb tshaj yog rau mob mob npas.

3. Rau kev kho mob ntawm mob caj dab thiab mob rheumatoid, qhov ua tau zoo yog 94.3% rau kev mob sib koom tes, mob nraub qaum, thiab mob pob qij txha.

4. Nws muaj qhov kho kom haum rau qhov mob voos thiab mob sib kis mob los ntawm qee cov kab mob thiab cov kab mob.

5. Tsis tas li ntawd, cov khoom lag luam no tseem tuaj yeem siv los tiv thaiv thiab tua kab mob txha caj qaum thiab mob ntshav caj pas. Nws muaj cov nyhuv antagonistic rau platelet kev sib xyaw los ntawm collagen thiab adenosine diphosphate, thiab tuaj yeem txo cov mob thrombosis.


Lub sij hawm tshaj tawm: Tsib Hlis-17-2021